Home

Ockie Fourie Toxicologists (OFT) are national and international independent toxicologists, specializing in toxicology and product risk and safety assessment with regard to human health and the environment. Our services encompasses the review and risk assessment of toxicological protocols and dossiers of novel and generic molecules destined for the agricultural industry, pre-clinical evaluation of pharmaceuticals, and the safety assessment of industrial chemical products in general.


During 25 years of consulting human health toxicology, ecotoxicology and the fate of chemicals in the environment, we have provided clients in all relevant industries, nationally and internationally, with guidance to the risk and safety of chemicals associated with the consumer and worker, as well as for target and non-target organisms in the environment.

Toxicology related to human health

In the toxicology related to human health, OFT are experienced in the risk assessment of inter alia the following studies:

  • acute and chronic toxicity studies
  • eye and dermal irritation
  • skin sensitization
  • reproduction and teratology
  • mutagenicity and genetic toxicology
  • carcinogenicity
  • pharmacokinetics (ADME)
  • neurotoxicity
  • endocrine disruption
  • immunotoxicity

Toxicology related to ecotoxicology
In the toxicology related to the ecology:

  • acute and chronic studies to aquatic organisms
  • acute and chronic studies to avian organisms
  • reproduction
  • non-target organisms such as earthworm and the honey bee
  • algae growth inhibition, and
  • soil micro- and macro organisms.

Environmental fate
Experience related to environmental fate inter alia includes

  • hydrolytic fate
  • photodegradation
  • metabolism in aerobic and anaerobic soils
  • mobility and dissipation studies
  • adsorption and desorption; and
  • fate of residues in plants, animals, poultry and ruminants.

Regulatory submissions
At OFT we specialize in the design of protocols, review and risk assessment of toxicological dossiers and data, and the preparation of summaries for regulatory submissions.